Norco and Vicodin are both prescription pain medications combining hydrocodone, an opioid, with acetaminophen, a non-opioid pain reliever. The primary difference lies in their acetaminophen content: Norco usually contains lower doses (325 mg) of acetaminophen per tablet, whereas Vicodin may contain higher amounts (up to 500 mg). https://medznow.com/norco-vs-vicodin/